New PDF release: Aminocyclitol Antibiotics

By Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)

ISBN-10: 084120554X

ISBN-13: 9780841205543

ISBN-10: 0841206929

ISBN-13: 9780841206922

content material: Aminocyclitol antibiotics : an advent / Kenneth L. Rinehart, Jr. and Lois S. guard --
Synthesis of aminocyclitol antibiotics / S. Umezawa --
amendment of aminocyclitol antibiotics / Tetsuo Suami --
Syntheses of some branched-chain aminocyclitol antibiotics / Juji Yoshimura, Masuo Funabashi, and Chung-Gi Shin --
a brand new synthesis of branched-chain epi-configuration deoxyhalogeno- and deoxyaminocyclitols / Donald E. Kiely and James M. Riordan --
The stereospecific synthesis of spectinomycin / D.R. White, R.D. Birkenmeyer, R.C. Thomas, S.A. Mizsak, and V.H. Wiley --
Synthesis of spectinomycin analogs / R.C. Thomas, D.R. White, V.H. Wiley, and D.A. Forster --
Spectinomycin amendment / W. Rosenbrook, Jr. and Ronald E. Carney --
The constructions of diastereomers of dihydrospectinomycins / Louise Foley and Manfred Weigele --
Chemical amendment of aminoglycosides : a unique synthesis of 6-deoxyaminoglycosides / Barney J. Magerlein --
The impact of O-methylation at the task of aminoglycosides / J.B. McAlpine, R.E. Carney, R.L. Devault, A.C. Sinclair, R.S. Egan, M. Cirovic, R. Stanaszek, and S. Mueller --
The synthesis and organic houses of 3'- and 4'-thiodeoxyneamines and 4'-thiodeoxykanamycin B / Thomas W. Ku, Robert D. Sitrin, David J. Cooper, John R.E. Hoover, and Jerry A. Weisbach --
Synthesis of analogs of kanamycin B / J.P.H. Verheyden, D.B. Repke, T.C. Tompkins, and J.G. Moffatt --
The selective N-acylation of kanamycin A / M.J. Cron, J.G. Keil, J.S. Lin, M.V. Ruggeri, and D. Walker --
Carbon-13 NMR spectra of aminoglycoside antibiotics / Takayuki Naito, Soichiro Toda, Susumu Nakagawa, and Hiroshi Kawaguchi --
The buildings of juvenile parts of the fortimicin advanced / J.B. McAlpine, R.S. Egan, R.S. Stanaszek, M. Cirovic, S.L. Mueller, R.E. Carney, P. Collum, E.E. Fager, A.W. Goldstein, D.J. Grampovnik, P. Kurath, J.R. Martin, G.G. submit, J.H. Seely, and J. Tadanier --
The constructions of latest fortimicins having double bonds of their purpurosamine moieties / Kunikatsu Shirahata, Gen Shimura, Seigo Takasawa, Takao Iida, and Keiichi Takahashi --
Enzymes editing aminocyclitol antibiotics and their roles in resistance selection and biosynthesis / Julian Davies --
Biosynthesis and mutasynthesis of aminocyclitol antibiotics / Kenneth L. Rinehart, Jr. --
Chemical and organic amendment of antibiotics of the gentamicin workforce --
P.J.L. Daniels, D.F. Rane, S.W. McCombie, R.T. Testa, J.J. Wright, and T.L. Nagabhushan --
Synthesis and mutasynthesis of pseudosaccharides regarding aminocyclitol-glycoside antibiotics / J. Cléophax, A. Roland, C. Colas, L. Castellanos, S.D. Géro, A.M. Sepulchre, and B. Quiclet --
a number of interactions of aminoglycoside antibiotics with ribosomes / Bernard D. Davis and Phang-C. Tai.

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Yamada, T . , Tipper, D. and Davies, J . , Nature, (1968), 219, 288. 47. , Tipper, D. and Davies, J . , J. , (1969), 100, 1144. 48. , Takahashi, N . , Kawabe, H. , International Symposium on Bacterial Resistance, Tokyo, October 1974. 49. , Takahashi, Y . , Usui, T. and Tsuchiya, T . , J. Antibiot. (Tokyo), (1974), 27, 997. 50. , Tsuchiya, T . , Yamazaki, T . , Sano, H. and Takahashi, Y . , J. Amer. Chem. , (1974), 96, 920. 51. , Yamazaki, T . , Kubota, Y. and Tsuchiya, T . , Bull. Chem. Soc. , (1975), 48, 563.

16). A l s o , compound was prepared by an a l t e r n a t i v e route ( F i g . 15) . When the epoxide, KK was heated w i t h sodium azide and ammonium c h l o r i d e i n 2-methoxyethanol, an azido d e r i v a t i v e was obtained, which was f u r t h e r converted t o SS i n a y i e l d of 7%, v i a compound TT (16). A n t i m i c r o b i a l a c t i v i t i e s of the amino-deoxyneamine were determined (Table 4 ) . A l l the compounds t e s t e d showed a marked decrease of the a c t i v i t y and t h e r e f o r e , an i n t r o d u c t i o n of one more amino group i n t o the 2-deoxystreptamine moiety of neamine, G i s not promising.

Muto, R. , Bull. Chem. Soc. , (1972), 45, 2842. 34. , Okazaki, Y. and Tsuchiya, T . , Bull. Chem. Soc. , (1972), 45, 3619. 35. Tipson, R. S. , Carbohyd. , (1965), 1, 338. 36. , Horton, D. and Tsuchiya, T . , Carbohyd. , (1966), 2, 349. 37. Jikihara, T . , Tsuchiya, T . , Umezawa, S. , Bull. Chem. Soc. , (1973), 46, 3507. 38. , Umezawa, H . , Okazaki, Y. and Tsuchiya, T . , Bull. Chem. Soc. , (1972), 45, 3624. 39. , Suzuki, T . , Tsuchiya, T . , Umezawa, S. , Bull. Chem. Soc. , (1973), 46, 3210.

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Aminocyclitol Antibiotics by Kenneth L. Rinehart, Jr. and Tetsuo Suami (Eds.)


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