By John E. Kay (auth.), Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (eds.)
Cyclosporin has had a awesome influence on medical organ transplantation. sooner than its advent, massive advances have been made within the grafting of significant organs, quite the kidney, center and liver. in lots of built nations, besides the fact that, transplantation used to be now not thought of wo-rthwhile by way of achieve for the funding of assets. the enhanced result of kidney grafts following using cyclosporin has replaced this perspective. for every type of organ transplantation, cyclosporin has led to an development of sensible graft survival and has allowed a discount in steroid dose and, every so often, no steroids in any respect. It has authorised the 1st profitable experimental transplantation of the center and lungs in primate species by means of Reitz and co-workers and their effects have been utilized on to the sanatorium. It used to be mostly as a result of advent of cyclosporin that the Washington Consensus assembly on Liver Transplantation got here to a beneficial suggestion and the outcome has been the proliferation of devices acting liver transplantation, nearly fifty in North the USA and one other fifty in Europe, the place formerly there were a handful. Having been interested in cyclosporin for organ grafting from the start, i've been capable of witness those advancements that have a ways handed my expectancies as soon as the nephrotoxicity of cyclosporin was once verified in guy. it truly is becoming that Dr.
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Additional resources for Cyclosporin: Mode of Action and Clinical Applications
A. D .. Tutschka. P. ). and Santos. G. W. (1982) Effect of cyclosporin on human lymphocyte response in vitro. Ill. CS inhibits the production of T lymphocyte growth factors in secondary mixed lymphocyte responses but does not inhibit the response of primed lymphocytes to TCGF. ]. Immunol .. 128. 355 18. Elliott. J. F.. Lin. Y.. MizeL S. B.. Bleackley. R. c.. Hamish. D. G. and Paetkau. V. (19114) Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science. 226. 1439 19. Granelli-Pipemo.
These initial studies clearly indicated that CsA effectively inhibited the proliferative response of T lymphocytes. However, they offered no insight into the action of CsA in preventing graft rejection, and could not account for the ability of esA to facilitate the induction of transplantation tolerance or for the prolonged survival of allogafts after discontinuation of esA treatment or reduction of dose? Similarly, inhibition of lymphocyte proliferation was only a simple measure of the efficacy of this immunosuppressive agent.
P. D .. Hape!. A. ).. Johnson. R. M .. Young. I. G. and Lafferty. K. J. (1987) 32 CsA MODULATION OF THE IL-2fIL-2 RECEPTOR PATHWAY 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. Blocking of the delivery of the antigen-mediated Signal to the nucleus of T cells by Cyclosporine. Transplmlla/ioll. 43, 685 Citterio, F. and Kahan, B. P. (1988) Effects of cydosporine on nuclear function. Trans. , 20 (SuppL 2). 75 June. C H Ledbetter. J. , Gellespie, M. , Lindtsen, T and Thompson, C B. (1987) T cell proll: eration involving the CD 28 pathway is associated with cycIosporine-resistant interleukir.
Cyclosporin: Mode of Action and Clinical Applications by John E. Kay (auth.), Angus W. Thomson BSc(Hons), MSc, PhD, DSc, MRCPath, FIBiol (eds.)