Download e-book for iPad: Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in by Steven H. Abman

By Steven H. Abman

ISBN-10: 1420076914

ISBN-13: 9781420076912

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Extra resources for Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in Health and Disease)

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Perlecan is involved in the control of smooth cell proliferation and differentiation since increased cell proliferation of fetal lung SMCs is accompanied by a highly increased synthesis of perlecan (203). Growth and branching of E13 mouse lung explants can be disrupted by inhibiting PG sulfation. The migration of epithelial cells toward invaded lung mesenchyme as well as toward beads soaked in FGF10 is inhibited when PG sulfation fails; chlorate severely decreased branching morphogenesis in lung mesenchymal and epithelial tissue recombinants (204).

5, Hfh-8 expression is restricted to the distal lung mesenchyme and the muscular layer of the bronchi (46). One important regulated target of HFH8 is Pdgf receptor that is also expressed in mesenchyme (15,47,48). The level of Hfh-8 expression is important for normal lung development, as an alveolar hemorrhage phenotype is observed in Hfh8 (þ/À) mice, while Hfh8 (À/À) mice died in utero. In addition, reduction of Hfh-8 expression in Hfh-8+/À mutants is accompanied by decreased expression of VEGF and its receptor 2 (Flk-1), BMP4, and the transcription factors of the Brachyury T-Box family (Tbx2–Tbx5) and lung Kruppel-like factor (49).

Therefore, Gli2 plays an important role in the asymmetric patterning of the lung. B. Peptide Growth Factors That Mediate Lung Morphogenesis E11 mouse embryo lung can grow and branch spontaneously in serum-free medium in vitro. A variety of growth factors added into the culture medium can influence lung growth in the culture system (74,75). Such experiments indicate that the embryonic lung mesenchymal and epithelial cells can communicate through autocrine or paracrine factors. In this way, different signaling pathways are coordinated to control lung growth at the right time and right place.

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Bronchopulmonary Dysplasia, Volume 240 (Lung Biology in Health and Disease) by Steven H. Abman

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