New PDF release: Biophysics and Physiology of Carbon Dioxide: Symposium Held

By W. Knoche (auth.), Professor Dr. Christian Bauer, Professor Dr. Gerolf Gros, Professor Dr. Heinz Bartels (eds.)

ISBN-10: 3642675727

ISBN-13: 9783642675720

ISBN-10: 3642675743

ISBN-13: 9783642675744

This quantity comprises the papers offered on the symposium on Biophysics and body structure of Carbon Dioxide held at Regensburg, April 17-20, 1979. The manuscripts symbolize the complete or perhaps a longer account of the oral shows. we have now made up our minds to not contain any a part of the discussions which came about after the lectures simply because this might have ended in an undue expansion of the already massive quantity. The symposium introduced jointly a few 60 scientists of varied disciplines together with biophysicists, chemists, biochemists, physiologists, pharmacologists, in addition to clinicians whose study actions are cen­ tered round the a number of elements of the reactions and the regulatory function of CO in the physique. 2 In view of the truth that quite a few textbooks and lawsuits of Symposia deal expertly with the position of CO in acid-base stability, it 2 was once made up our minds to not contain this element within the current symposium. This holds additionally for the biochemistry of carboxylation and decarboxylation reactions. specific emphasis used to be put on the next topics: (1) Chemical reactions of CO in water and facilitated diffusion of CO2 , 2 (2) CO adducts to proteins, particularly hemoglobin, and peptide 2 hormones, (3) constitution and serve as of carbonic anhydrase, (4) CO 2 trade and carbonic anhydrase task in breathing and nonrespi­ ratory platforms. each one part includes at the very least one introductory paper that offers the present wisdom in a extra basic framework.

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Extra resources for Biophysics and Physiology of Carbon Dioxide: Symposium Held at the University of Regensburg (FRG) April 17–20, 1979

Example text

2 Measurement of Facilitated CO 2 Diffusion CO 2 fluxes were measured under steady-state conditions across thin layers of solution using an experimental set-up described previously (Gros and Moll, 1971; Gros and Moll, 1974). ) in the solution under investigation. Temperature was 25°C. Facilitated diffusion was usually quantitated by comparing the CO 2 diffusion coefficients (= total flux of CO2 per concentration difference of dissolved CO2) obtained in a low CO 2 partial pressure range (pC0 2 values at the boundaries of the layers about 2 and 3 torr, respectively) with the CO 2 diffusion coefficients obtained in a high pC02 range (boundary pC02 values 200 and 600 torr , respectively).

At a concentration of 3 g% about 60% of the total flux seems to be due to translational transport, at 26 g% only about 1/4 ofthe total flux can be explained by translational diffusion. ,, • Dpcs' o Dtrans , 10 20 30 Earthworm hemoglobin concentration (g/100ml) Fig. 3. Diffusion coefficient of earthworm hemoglobin in cm 2 s- 1 , DEW-Hb' as a function of earthworm hemoglobin concentration in g%. 0 indicate the directly measured translational diffusion coefficients of earthworm hemoglobin, Dtrans (quoted from Gros, 1978); • represent the protein diffusivities that have to be postulated to explain the facilitated CO 2 fluxes measured in earthworm hemoglobin solutions (see Fig.

Thus, translational diffusion can only explain part of the measured facilitated proton fluxes. At a concentration of 3 g% about 60% of the total flux seems to be due to translational transport, at 26 g% only about 1/4 ofthe total flux can be explained by translational diffusion. ,, • Dpcs' o Dtrans , 10 20 30 Earthworm hemoglobin concentration (g/100ml) Fig. 3. Diffusion coefficient of earthworm hemoglobin in cm 2 s- 1 , DEW-Hb' as a function of earthworm hemoglobin concentration in g%. 0 indicate the directly measured translational diffusion coefficients of earthworm hemoglobin, Dtrans (quoted from Gros, 1978); • represent the protein diffusivities that have to be postulated to explain the facilitated CO 2 fluxes measured in earthworm hemoglobin solutions (see Fig.

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Biophysics and Physiology of Carbon Dioxide: Symposium Held at the University of Regensburg (FRG) April 17–20, 1979 by W. Knoche (auth.), Professor Dr. Christian Bauer, Professor Dr. Gerolf Gros, Professor Dr. Heinz Bartels (eds.)


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