By Jonathan Pevsner
The bestselling creation to bioinformatics and practical genomics. Bioinformatics and useful Genomics deals the main broad-based advent to this explosive new self-discipline.
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Additional info for Bioinformatics and Functional Genomics
Thefirst perspective of the field of bioinformatics is the ceU. Bioinformatics has emerged as a discipline as biology has become transformed by the emergence of molecular sequence data. , GenBank, and the D N A Database qf Japan (DDBJ) sewe as repositories for billions of nucleotides of D N A sequence' data (see Chapter 2). Corresponding databases of expressedgenes (RNA) and protein have been established. A main focus of the field of bioinformatics is to study molecular sequence data to gain insight into a broad range of biological problems.
RBP4 is also sometimes called RBP. In general, a gene does not always have the same name as the corresponding protein. HD is the gene symbol for the gene that causes Huntingon disease; the gene name corresponds to the phenotype. e. protein) is called huntingtin. Often, multiple investigators study the same gene or protein and assign different names. The human genome organization (HUGO) Gene Nomenclature Committee (HGNC) has the critical task of assigning official names to genes and proteins. uk/ nomenclature/.
We are also coming to appreciate the power of comparative genomics, in which genomes are compared. 4 on the following page presents the contents of this book in the context of the three perspectives of bioinformatics. A CONSISTENT EXAMPLE:RETINOL-BINDING PROTEIN Throughout this book we will focus on the example of a gene and its corresponding protein product: retinol-binding protein (RBP4), a small, abundant secreted protein that binds retinol (vitamin A) in blood (Newcomer and Ong, 2000). Retinol, obtained from carrots in the form of vitamin A, is very hydrophobic.
Bioinformatics and Functional Genomics by Jonathan Pevsner