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By W. E. Johns

Professor Max Beklinder has disappeared. he's the inventor of Linderite explosive, a Lucranian via beginning yet British through naturalization. The Professor was once engaged on a mystery poison gasoline for the British whilst he was once pronounced as having been killed in a vehicle coincidence in Unterhamstadt in Lucrania. Biggles is distributed to determine if he's quite lifeless and if now not, to get him again. Algy flies over to Lucrania and Biggles and Ginger parachute down. They intend to pose as British travelers and check out to set up the reality in regards to the Professor's dying. It's now not lengthy sooner than they detect the Professor's Morris Ten automobile thoroughly undamaged, hidden in a close-by citadel. Staying at a lodge in Unterhamstadt, Biggles and Ginger trigger to discover the vault the place the Professor is supposedly buried. In his coffin, they locate simply books, yet a mysterious woman has them. the lady is staying at Biggles and Ginger's resort. The neighborhood police raid the inn and trap the "girl" and it seems that it truly is a guy in hide - Beklinder's son. Lucrania is below the heel of 1 of its neighbours, and a local of that nation is accountable for the police. Erich von Stalhein is on the lodge checking the names of the visitors and is shocked to come across of his outdated foes. With mins to spare, Biggles and Ginger get away right into a mystery passage that leads from room 17 within the inn to the citadel. The passage leads in the back of the citadel partitions and Ginger comes throughout a undercover agent gap right into a room that's getting used as von Stalhein's place of work. To Ginger's astonishment he sees that Algy is a prisoner! Von Stalhein additionally has Professor Beklinder as a prisoner. The Professor threatens von Stalhein with a few robust explosive he has made yet von Stalhein has a trump card to play within the type of Beklinder's captured son. Beklinder has at hand the explosive over. Von Stalhein plans to take the Beklinders away and Biggles and Ginger recognize they have to cease this. They seize the auto taking the Beklinders out of the fortress and race to discover Algy's airplane however it is just too past due as von Stalhein has had the aircraft got rid of. Biggles has a plan and tells Ginger that he and the Beklinders needs to meet him at a undeniable rendezvous at 12.20 a.m. meanwhile they're to conceal up on the vault whereas Biggles attempts to organise a few delivery. within the vault, the Professor tells Ginger that there's additionally a mystery passage from the vault to the fortress. utilizing this, Ginger returns to rescue Algy, whatever he succeeds in doing with slightly aid from Beklinder's explosive. Ginger and Algy rush to the vault and locate that the Beklinders have already trigger. Catching up with them, the 4 males wait on the rendezvous, yet already the warriors are out monitoring them with canine. in the meantime Biggles has long past to Prenzel, as he understands commonplace mail airplane leaves for Croydon at nighttime. He hopes to cajole the pilot to assist him. issues don't fairly visit plan and Biggles has to scouse borrow the airplane. He flies to the rendezvous and is simply in time to load his passengers aboard and make a determined flight again to England.

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5). Based on previous correlations between the positioning of Hl2 and the ability of ERa and other NRs to form coactivator complexes , the conformation of the ERp LBD observed in both the THC and GEN complexes (Fig. 5) should be incapable of interacting with coactivators and, hence, should be transcriptionally silent for two reasons. First, key residues from helix 12 (Leu 490, Glu 493, and Met 494) that are predicted to form part of the coactivator recognition surface are inappropriately positioned.

We next used an antisense approach to assess MNAR' s role in estrogen regulation of gene transcription . MCF-7 cells were transfected with antisense or sense control oligonucleotides, total RNA was isolated, and TaqMan analysis was performed using a primer/ probe set designed to target MNAR, pS2 and cathepsin D - two genes known to be regulated by estrogens in MCF-7 cells. Levels of MNAR, pS2 and cathepsin D mRNA, normalized to GAPDH mRNA, are presented in Fig. 5 C. Expression of MNAR was substantially stimulated by E2 treatment.

Science 270:1491-1494 Kato S, Masuhiro Y, Watanabe M, Kobayashi Y, Takeyama K1, Endoh H, Yanagisawa J (2000) Molecular mechanism of a cross-talk between estrogen and growth factor signaling pathways. Genes Cells 5:593-601 Kato S, Sasaki H, Suzawa M, Masushige S, Tora L, Chambon P, Gronemeyer H (1995b) Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors. Mol Cell Bioi 15:5858-5867 Kay BK, Williamson MP, Sudol M (2000) The importance of being proline : the interaction of proline-rich motifs in signaling proteins with their cognate domains.

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Biggles - Secret Agent by W. E. Johns

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