Get Behavioral Neurobiology of the Endocannabinoid System PDF

By Stephen P. H. Alexander, David A. Kendall (auth.), Dave Kendall, Stephen Alexander (eds.)

ISBN-10: 354088954X

ISBN-13: 9783540889540

The endocannabinoid signalling method is likely one of the key modulators of primary apprehensive functionality. This quantity presents well timed and in-depth insurance of the jobs of the endocannabinoid signalling method within the neurobiology of habit. it's crucial analyzing for any researcher with a history in neuroscience eager to be aware of extra concerning the endocannabinoids. the 1st part presents a accomplished account of the part elements of the process (the signalling molecules, man made and degradative enzymes and receptors), their place in the vital anxious process and the endocannabinoids’ roles in neural plasticity. This part additionally describes the toolboxes (genetic and pharmacological) used to review the process. the second one part concentrates on endocannabinoid functionality within the keep watch over of ordinary physiological behaviors together with a connection with the evolution of the method in keeping with its operation in non-mammalian vertebrates. the quantity concludes through addressing the significance of the endocannabinoids in pathological behaviors together with affective and cognitive problems, neurodegenerative stipulations, feeding and drug abuse.

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Extra info for Behavioral Neurobiology of the Endocannabinoid System

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2008) Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg Med Chem Lett 18:5838–5841 Hu SSJ, Bradshaw HB, Chen JSC et al. (2008) Prostaglandin E-2 glycerol ester, an endogenous COX-2 metabolite of 2-arachidonoylglycerol, induces hyperalgesia and modulates NFkB activity. Br J Pharmacol 153:1538–1549 Inoue M, Okuyama H (1984) Phospholipase A1 acting on phosphatidic acid in porcine platelet membranes. J Biol Chem 259:5083–5086 Jaye M, Lynch KJ, Krawiec J et al.

38 Receptor Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 GPCR Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Radioligand Binding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 GTPgS Binding as a Measure of GPCR Function . . . . . . . . . . . . . . . . . . 41 CB1 Receptor Gene Structure .

38 Receptor Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 GPCR Signaling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Radioligand Binding. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 GTPgS Binding as a Measure of GPCR Function . . . . . . . . . . . . . . . . . . 41 CB1 Receptor Gene Structure .

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Behavioral Neurobiology of the Endocannabinoid System by Stephen P. H. Alexander, David A. Kendall (auth.), Dave Kendall, Stephen Alexander (eds.)


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