Antimicrobial Drug Action - download pdf or read online

By D. I. Edwards

ISBN-10: 0333235681

ISBN-13: 9780333235683

ISBN-10: 1349163600

ISBN-13: 9781349163601

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Winston eds), Cold Spring Harbor Publications, New York, pp. 1473-82 Schubert, J. (1970). Formation of cell growth inhibition by chemicals and environmental agents. f. gen. , 64, 37-40 Zahner, H. and Maas, W. K. (1972). Biology of Antibiotics. 1 INTRODUCTION A knowledge of how antimicrobial drugs are biosynthesised is essential for the production and purification of such drugs and provides a means whereby new drugs can be synthesised chemically. All the major antibiotics in use today are produced by bacteria or fungi with the exception of small antibiotic molecules such as chloramphenicol which can be synthesised chemically.

16 Formation of poly ketones from acetate. 16. In the following, the biosynthesis of tetracyclines and griseofulvin will be shown as examples of fused ring antibiotics, erythromycin as an example of macrolide biosynthesis, and amphotericin B as an example of polyene biosynthesis. 1 Tetracyclines The elucidation of tetracycline biosynthesis, largely the work of McCormack and his colleagues, is a complex story involving the analysis of tetracycline synthesis in mutant organisms. In all about seven mutations in different parts of the pathway were used before the complete II-stage synthesis was elucidated.

The sugar skeletons of desosamine and L-cladosine both originate from glucose and their attached methyl groups come from the methyl group of methionine. 20 shows the biogenetic origin of the various components of erythromycin. 20 Structure and biogenetic origin of erythromycin. The bold points indicate that the carbons of, and attached to, the macrolide ring are derived from propionate units. The C-methyl groups of cladinose and the N-methyl groups of desosamine are all derived from methionine, and both sugar rings derive from glucose.

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Antimicrobial Drug Action by D. I. Edwards

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