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By M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview

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Extra info for Acetylcholine. An Approach to the Molecular Mechanism of Action

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The equilibrium potential of the IPSP is only a few millivolts (5-10 mV) lower than the resting membrane potential. The IPSP is thus manifest as a slight hyperpolarization, and its main function is to stabilize the membrane potential close to the resting level. e. the EPSP must be of greater size in order to elicit excitation. 6. Hypotheses concerning the Mechanism of the Change in Permeability of the Postsynaptic Membrane under the Influence of the Mediator While studying the interaction of ACh and its analogues with ChE, Wilson and Cabib (1956) showed that the formation of the complex was associated with a profound alteration in the structure of the AChE molecule, due to changes in its tertiary structure.

Even the existence of chemical transmission of nerve impulses in coelenterates has not yet been established. In the course of 400 million years of independent development Nature has found not only the chemical principle of transmission of nervous excitation, but also ACh as one of the mediators for both main branches of the phylogenetic tree. Among the examples of all types of animals, in which this question has been studied, ACh is not the only mediator. e. noradrenaline with a small admixture of adrenaline), glutamic acid, gamma-amino-butyric acid, glycine and possibly 5-hydroxytryptamine (serotonin).

1972). Cholinolytic substances that readily penetrate the brain upset higher nervous activity, and these disturbances can be prevented with anticholinesterase preparations (Fig. 10). Atropine-like cholinolytic substances slow down the elaboration of conditioned reflexes, while cholinomimetic substances (nicotine, arecoline) accelerate the process (Fig. 9 1954, 1957b, 1965; Lukomskaya, 1957a, b; Michelson, 1957, 1959, 1961; Rozhkova, 1957; Savateyev, 1957a, b, c; Michelson and Shchelkunov, 1963; Bovet and Gatti, 1965; Linyuchev and Michelson, 1965, 1967).

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Acetylcholine. An Approach to the Molecular Mechanism of Action by M. J. Michelson,E. V. Zeimal,P. Alexander, et al.Elsevier|Elsevier Science||Pergamon Flexible LearningAdult NonfictionScienceLanguage(s): EnglishOn sale date: 08.12.2014Street date: 17.05.2014Preview


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